Longevity

Building a longevity stack: NAD+, glutathione, and B12 together

How three of the most-requested longevity injections complement each other — and a sample weekly cadence members actually run.

DM
Dr. Marcus Chen, MD
Longevity & regenerative medicine
May 7, 20265 min read
Building a longevity stack: NAD+, glutathione, and B12 together
Key takeaways
  • No single injection does everything — stacks cover energy, detox, and recovery.
  • A common cadence: NAD+ x3, glutathione x2, B12 x1 per week.
  • Clinician personalization based on labs always wins over copy-paste protocols.

No single injection does everything. The members who feel the biggest shift over a quarter usually run a stack — each piece doing something the others can't.

The roles

  • NAD+ — mitochondrial energy and DNA repair
  • Glutathione — oxidative stress and liver detox
  • B12 — red blood cells, nerves, and methylation

A realistic weekly cadence

A common rhythm: NAD+ three mornings a week, glutathione twice, B12 once. Clinicians personalize this based on labs, goals, and tolerance — but it's a starting point that's worked for thousands of members.

"Stacks aren't about doing more. They're about each piece covering what the others can't."
Dr. Marcus Chen, MD

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